Drug interactions
Prazosin + Tolfenamic acid
Severity: Minor
Prazosin and Tolfenamic acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as tolfenamic acid can blunt the blood pressure lowering effect of antihypertensives through sodium and fluid retention. The effect on prazosin is generally modest but may reduce blood pressure control.
What this interaction means in plain words
Prazosin and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Prazosin belongs to Genitourinary; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
NSAID inhibition of prostaglandin synthesis causes sodium and water retention and vasoconstriction, opposing the vasodilating effect of prazosin.
What to do
Monitor blood pressure when an NSAID is started or used regularly with prazosin. Use the lowest effective NSAID dose for the shortest time.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Prazosin with Tolfenamic acid?
MediHelp rates the interaction as minor. Prazosin and Tolfenamic acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs such as tolfenamic acid can blunt the blood pressure lowering effect of antihypertensives through sodium and fluid retention. The effect on prazosin is generally modest but may reduce blood pressure control.
How serious is the interaction between Prazosin and Tolfenamic acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure when an NSAID is started or used regularly with prazosin. Use the lowest effective NSAID dose for the shortest time.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
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