Drug interactions
Prazosin + Treprostinil
Severity: Moderate
Prazosin and Treprostinil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Treprostinil is a prostacyclin analog that causes vasodilation and can lower blood pressure. Combined with prazosin the hypotensive effect may be additive, with dizziness or syncope.
What this interaction means in plain words
Prazosin and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prazosin belongs to Genitourinary; Treprostinil belongs to Cardiovascular.
Why it happens
Additive vasodilation through prostacyclin receptor agonism and alpha-1 blockade.
What to do
Monitor blood pressure and symptoms of hypotension when starting or titrating treprostinil. Reduce the prazosin dose if hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Other interactions of Treprostinil
Frequently asked questions
Can I take Prazosin with Treprostinil?
MediHelp rates the interaction as moderate. Prazosin and Treprostinil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Treprostinil is a prostacyclin analog that causes vasodilation and can lower blood pressure. Combined with prazosin the hypotensive effect may be additive, with dizziness or syncope.
How serious is the interaction between Prazosin and Treprostinil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and symptoms of hypotension when starting or titrating treprostinil. Reduce the prazosin dose if hypotension occurs.
What other medicines interact with Prazosin?
MediHelp also lists interactions of Prazosin with, for example, Alfuzosin, Amifostine, Avanafil. The full list is on the Prazosin page.
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