Drug interactions
Prazosin + Verapamil
Severity: Moderate
Prazosin and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combined use can cause additive blood pressure reduction, with first-dose or orthostatic hypotension and dizziness. Verapamil may also raise prazosin exposure.
What this interaction means in plain words
Prazosin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prazosin belongs to Genitourinary; Verapamil belongs to Cardiovascular.
Why it happens
Additive vasodilatory effects from calcium channel blockade and alpha-1 blockade, with possible reduced prazosin clearance.
What to do
Monitor blood pressure including standing readings, and start prazosin at a low dose. Adjust either dose if symptomatic hypotension occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Prazosin
- Alfuzosin + Prazosin Major
- Amifostine + Prazosin Major
- Avanafil + Prazosin Major
- Doxazosin + Prazosin Major
- Dutasteride-tamsulosin + Prazosin Major
- Phenoxybenzamine + Prazosin Major
Frequently asked questions
Can I take Prazosin with Verapamil?
MediHelp rates the interaction as moderate. Prazosin and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combined use can cause additive blood pressure reduction, with first-dose or orthostatic hypotension and dizziness. Verapamil may also raise prazosin exposure.
How serious is the interaction between Prazosin and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure including standing readings, and start prazosin at a low dose. Adjust either dose if symptomatic hypotension occurs.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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