Drug interactions
Prednisolone + Trastuzumab
Severity: Moderate
Prednisolone and Trastuzumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents can contribute to infection risk, since corticosteroids are immunosuppressive and trastuzumab increases neutropenia when combined with chemotherapy. In oncology regimens the combination is common, but infection vigilance is needed.
What this interaction means in plain words
Prednisolone and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisolone belongs to Endocrine; Trastuzumab belongs to Oncology.
Why it happens
Additive immunosuppression and, with chemotherapy, myelosuppression; no direct pharmacokinetic interaction.
What to do
Monitor blood counts and for signs of infection, particularly neutropenic fever. Use the lowest effective corticosteroid dose and treat infections promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Other interactions of Trastuzumab
Frequently asked questions
Can I take Prednisolone with Trastuzumab?
MediHelp rates the interaction as moderate. Prednisolone and Trastuzumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents can contribute to infection risk, since corticosteroids are immunosuppressive and trastuzumab increases neutropenia when combined with chemotherapy. In oncology regimens the combination is common, but infection vigilance is needed.
How serious is the interaction between Prednisolone and Trastuzumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and for signs of infection, particularly neutropenic fever. Use the lowest effective corticosteroid dose and treat infections promptly.
What other medicines interact with Prednisolone?
MediHelp also lists interactions of Prednisolone with, for example, Bcg vaccine live, Measles mumps and rubella vaccine live, Measles mumps rubella and varicella vaccine live. The full list is on the Prednisolone page.
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