Drug interactions
Prednisone + Quinupristin / dalfopristin
Severity: Minor
Prednisone and Quinupristin / dalfopristin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Quinupristin/dalfopristin inhibits CYP3A4 and may raise exposure to prednisolone, the active form of prednisone. This could increase glucocorticoid adverse effects such as fluid retention, hyperglycemia and mood changes. The effect is generally modest for prednisone compared with other corticosteroids.
What this interaction means in plain words
Prednisone and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Quinupristin/dalfopristin inhibits CYP3A4, which contributes to the metabolism of prednisolone.
What to do
No empirical dose change is usually needed; watch for corticosteroid excess during prolonged co-therapy. Reduce the prednisone dose if signs of excess appear.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Prednisone with Quinupristin / dalfopristin?
MediHelp rates the interaction as minor. Prednisone and Quinupristin / dalfopristin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Quinupristin/dalfopristin inhibits CYP3A4 and may raise exposure to prednisolone, the active form of prednisone. This could increase glucocorticoid adverse effects such as fluid retention, hyperglycemia and mood changes. The effect is generally modest for prednisone compared with other corticosteroids.
How serious is the interaction between Prednisone and Quinupristin / dalfopristin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is usually needed; watch for corticosteroid excess during prolonged co-therapy. Reduce the prednisone dose if signs of excess appear.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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