Drug interactions
Prednisone + Rabies vaccine chick embryo cell derived
Severity: Major
Prednisone and Rabies vaccine chick embryo cell derived: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Immunosuppressive doses of prednisone may reduce the antibody response to this inactivated rabies vaccine, leaving protection uncertain. There is no replication risk because the vaccine is non-live.
What this interaction means in plain words
Prednisone and Rabies vaccine chick embryo cell derived can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Corticosteroid suppression of immune function reduces the antibody response to the vaccine.
What to do
For post-exposure prophylaxis, give the full vaccine series with immune globulin and measure neutralizing antibody titres afterwards. For pre-exposure use, delay vaccination if possible until steroid exposure is minimized.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Prednisone with Rabies vaccine chick embryo cell derived?
MediHelp rates the interaction as major. Prednisone and Rabies vaccine chick embryo cell derived can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Immunosuppressive doses of prednisone may reduce the antibody response to this inactivated rabies vaccine, leaving protection uncertain. There is no replication risk because the vaccine is non-live.
How serious is the interaction between Prednisone and Rabies vaccine chick embryo cell derived?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For post-exposure prophylaxis, give the full vaccine series with immune globulin and measure neutralizing antibody titres afterwards. For pre-exposure use, delay vaccination if possible until steroid exposure is minimized.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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