Drug interactions
Prednisone + Retifanlimab
Severity: Moderate
Prednisone and Retifanlimab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids given before or at the start of PD-1 blockade may blunt the immune response and reduce efficacy. Corticosteroids remain appropriate for treating immune-related adverse reactions after starting retifanlimab.
What this interaction means in plain words
Prednisone and Retifanlimab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Retifanlimab belongs to Oncology.
Why it happens
Pharmacodynamic antagonism: corticosteroid immunosuppression counteracts T-cell activation by PD-1 blockade.
What to do
Avoid starting immunosuppressive doses of prednisone before retifanlimab unless essential; physiological doses up to 10 mg/day are acceptable. Use corticosteroids as needed to manage immune-related reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Retifanlimab
- Piperacillin-tazobactam + Retifanlimab Moderate
- Piperacillin + Retifanlimab Moderate
- Penicillin g + Retifanlimab Minor
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Prednisone with Retifanlimab?
MediHelp rates the interaction as moderate. Prednisone and Retifanlimab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids given before or at the start of PD-1 blockade may blunt the immune response and reduce efficacy. Corticosteroids remain appropriate for treating immune-related adverse reactions after starting retifanlimab.
How serious is the interaction between Prednisone and Retifanlimab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid starting immunosuppressive doses of prednisone before retifanlimab unless essential; physiological doses up to 10 mg/day are acceptable. Use corticosteroids as needed to manage immune-related reactions.
What other medicines interact with Retifanlimab?
MediHelp also lists interactions of Retifanlimab with, for example, Piperacillin-tazobactam, Piperacillin, Penicillin g. The full list is on the Retifanlimab page.
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