Drug interactions
Prednisone + Saquinavir
Severity: Minor
Prednisone and Saquinavir: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Prednisone may modestly induce CYP3A4 and lower saquinavir levels, but the effect is not well characterized. Conversely, ritonavir-boosted saquinavir can raise prednisolone exposure. Clinical consequences are uncertain.
What this interaction means in plain words
Prednisone and Saquinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible weak CYP3A4 induction by prednisone; saquinavir also inhibits CYP3A4, so the net effect is uncertain.
What to do
Monitor HIV viral load during extended high-dose corticosteroid therapy. Watch for corticosteroid excess if saquinavir is boosted with ritonavir.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Prednisone with Saquinavir?
MediHelp rates the interaction as minor. Prednisone and Saquinavir have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Prednisone may modestly induce CYP3A4 and lower saquinavir levels, but the effect is not well characterized. Conversely, ritonavir-boosted saquinavir can raise prednisolone exposure. Clinical consequences are uncertain.
How serious is the interaction between Prednisone and Saquinavir?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor HIV viral load during extended high-dose corticosteroid therapy. Watch for corticosteroid excess if saquinavir is boosted with ritonavir.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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