Drug interactions
Prednisone + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Prednisone and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Bowel preparations cause fluid loss and electrolyte shifts, and corticosteroids can contribute to potassium loss. Together they may increase the risk of hypokalemia, hypomagnesemia and dehydration, with possible arrhythmia.
What this interaction means in plain words
Prednisone and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive electrolyte disturbance from osmotic and stimulant catharsis and corticosteroid mineralocorticoid-mediated potassium loss.
What to do
Ensure adequate hydration and check electrolytes beforehand in patients on long-term prednisone, especially with cardiac disease or diuretic use. Correct potassium and magnesium abnormalities.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Prednisone with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Prednisone and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Bowel preparations cause fluid loss and electrolyte shifts, and corticosteroids can contribute to potassium loss. Together they may increase the risk of hypokalemia, hypomagnesemia and dehydration, with possible arrhythmia.
How serious is the interaction between Prednisone and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ensure adequate hydration and check electrolytes beforehand in patients on long-term prednisone, especially with cardiac disease or diuretic use. Correct potassium and magnesium abnormalities.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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