Drug interactions
Prednisone + Squill
Severity: Moderate
Prednisone and Squill: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Squill contains cardiac glycosides, and corticosteroid-induced hypokalemia can increase the risk of glycoside toxicity and arrhythmias. This is particularly relevant with prolonged or high-dose steroid use.
What this interaction means in plain words
Prednisone and Squill can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Corticosteroid mineralocorticoid effects cause potassium loss, sensitizing the myocardium to cardiac glycosides.
What to do
Monitor serum potassium and magnesium and correct deficits. Watch for signs of glycoside toxicity, or avoid squill preparations.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Prednisone with Squill?
MediHelp rates the interaction as moderate. Prednisone and Squill can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Squill contains cardiac glycosides, and corticosteroid-induced hypokalemia can increase the risk of glycoside toxicity and arrhythmias. This is particularly relevant with prolonged or high-dose steroid use.
How serious is the interaction between Prednisone and Squill?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium and magnesium and correct deficits. Watch for signs of glycoside toxicity, or avoid squill preparations.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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