Drug interactions
Prednisone + Tesamorelin
Severity: Moderate
Prednisone and Tesamorelin: moderate interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tesamorelin increases growth hormone and IGF-1, which may inhibit 11-beta-hydroxysteroid dehydrogenase type 1. This can reduce conversion of cortisone and prednisone to active forms, decreasing glucocorticoid effect.
What this interaction means in plain words
Prednisone and Tesamorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Growth hormone axis activation inhibits 11β-HSD1, reducing activation of prednisone to prednisolone.
What to do
Monitor for reduced steroid effect and signs of adrenal insufficiency in patients on replacement. Increase the prednisone dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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References
- EGRIFTA SV - FDA drug label (DailyMed) — openFDA / DailyMed
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Prednisone with Tesamorelin?
MediHelp rates the interaction as moderate. Prednisone and Tesamorelin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tesamorelin increases growth hormone and IGF-1, which may inhibit 11-beta-hydroxysteroid dehydrogenase type 1. This can reduce conversion of cortisone and prednisone to active forms, decreasing glucocorticoid effect.
How serious is the interaction between Prednisone and Tesamorelin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced steroid effect and signs of adrenal insufficiency in patients on replacement. Increase the prednisone dose if needed.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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