Drug interactions
Prednisone + Tislelizumab
Severity: Moderate
Prednisone and Tislelizumab: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic corticosteroids at higher doses before starting tislelizumab may blunt the immune response needed for its antitumor effect. Corticosteroids remain appropriate for treating immune-related adverse reactions after treatment begins.
What this interaction means in plain words
Prednisone and Tislelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Prednisone belongs to Endocrine; Tislelizumab belongs to Oncology.
Why it happens
Corticosteroid immunosuppression may counteract T-cell activation produced by PD-1 blockade.
What to do
Avoid baseline systemic prednisone above about 10 mg daily before starting tislelizumab where possible. Use corticosteroids as needed to treat immune-related adverse reactions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Tislelizumab
- Amoxicillin-clavulanic acid + Tislelizumab Moderate
- Amoxicillin + Tislelizumab Moderate
- Piperacillin-tazobactam + Tislelizumab Moderate
- Piperacillin + Tislelizumab Moderate
- Penicillin g + Tislelizumab Minor
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Prednisone with Tislelizumab?
MediHelp rates the interaction as moderate. Prednisone and Tislelizumab can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic corticosteroids at higher doses before starting tislelizumab may blunt the immune response needed for its antitumor effect. Corticosteroids remain appropriate for treating immune-related adverse reactions after treatment begins.
How serious is the interaction between Prednisone and Tislelizumab?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid baseline systemic prednisone above about 10 mg daily before starting tislelizumab where possible. Use corticosteroids as needed to treat immune-related adverse reactions.
What other medicines interact with Tislelizumab?
MediHelp also lists interactions of Tislelizumab with, for example, Amoxicillin-clavulanic acid, Amoxicillin, Piperacillin-tazobactam. The full list is on the Tislelizumab page.
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