Drug interactions
Prednisone + Typhoid polysaccharide vaccine
Severity: Minor
Prednisone and Typhoid polysaccharide vaccine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
This non-live vaccine is safe to give, but immunosuppressive prednisone doses may reduce the antibody response. Protection may be incomplete.
What this interaction means in plain words
Prednisone and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Corticosteroid suppression of B-cell function reduces vaccine-induced antibody production.
What to do
Vaccinate at least 2 weeks before travel where possible, and reinforce food and water precautions in patients on high-dose steroids.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Prednisone with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as minor. Prednisone and Typhoid polysaccharide vaccine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. This non-live vaccine is safe to give, but immunosuppressive prednisone doses may reduce the antibody response. Protection may be incomplete.
How serious is the interaction between Prednisone and Typhoid polysaccharide vaccine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before travel where possible, and reinforce food and water precautions in patients on high-dose steroids.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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