Drug interactions
Prednisone + Typhoid vaccine live
Severity: Major
Prednisone and Typhoid vaccine live: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The oral live attenuated typhoid vaccine may cause systemic Salmonella Typhi infection in immunosuppressed patients, and prednisone may also reduce its efficacy. Antibiotics taken concurrently would further inactivate the live bacteria.
What this interaction means in plain words
Prednisone and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Corticosteroid-induced immunosuppression impairs control of the live attenuated bacteria and reduces vaccine response.
What to do
Avoid the live oral vaccine in patients on immunosuppressive prednisone doses and use the inactivated injectable typhoid vaccine instead.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Prednisone
- Bcg vaccine live + Prednisone Contraindicated
- Measles vaccine + Prednisone Contraindicated
- Mifepristone + Prednisone Contraindicated
- Prednisone + Radium-223 dichloride Contraindicated
- Prednisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Prednisone Major
Frequently asked questions
Can I take Prednisone with Typhoid vaccine live?
MediHelp rates the interaction as major. Prednisone and Typhoid vaccine live can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. The oral live attenuated typhoid vaccine may cause systemic Salmonella Typhi infection in immunosuppressed patients, and prednisone may also reduce its efficacy. Antibiotics taken concurrently would further inactivate the live bacteria.
How serious is the interaction between Prednisone and Typhoid vaccine live?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live oral vaccine in patients on immunosuppressive prednisone doses and use the inactivated injectable typhoid vaccine instead.
What other medicines interact with Prednisone?
MediHelp also lists interactions of Prednisone with, for example, Bcg vaccine live, Measles vaccine, Mifepristone. The full list is on the Prednisone page.
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