Drug interactions
Nadolol + Prilocaine
Severity: Minor
Nadolol and Prilocaine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Local anesthetics given with beta-blockers may add to hypotension and bradycardia, especially if a large dose is absorbed systemically or injected intravascularly. Clinically significant effects are uncommon with usual dental or infiltration doses.
What this interaction means in plain words
Nadolol and Prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Nadolol belongs to Cardiovascular; Prilocaine belongs to Central Nervous System.
Why it happens
Additive cardiovascular depression from local anesthetic sodium channel blockade and beta-adrenergic blockade.
What to do
Use the lowest effective prilocaine dose with careful aspiration, and monitor heart rate and blood pressure in patients on nadolol, particularly with larger volumes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Prilocaine
- Bupivacaine implant + Prilocaine Major
- Nitric oxide + Prilocaine Major
- Phenazopyridine + Prilocaine Major
- Prilocaine + Propranolol Moderate
- Prilocaine + Timolol Moderate
- Hyaluronidase + Prilocaine Minor
Other interactions of Nadolol
- Acebutolol + Nadolol Major
- Adrenaline-articaine + Nadolol Major
- Albuterol + Nadolol Major
- Amifostine + Nadolol Major
- Amiodarone + Nadolol Major
- Arformoterol + Nadolol Major
Frequently asked questions
Can I take Nadolol with Prilocaine?
MediHelp rates the interaction as minor. Nadolol and Prilocaine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Local anesthetics given with beta-blockers may add to hypotension and bradycardia, especially if a large dose is absorbed systemically or injected intravascularly. Clinically significant effects are uncommon with usual dental or infiltration doses.
How serious is the interaction between Nadolol and Prilocaine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective prilocaine dose with careful aspiration, and monitor heart rate and blood pressure in patients on nadolol, particularly with larger volumes.
What other medicines interact with Prilocaine?
MediHelp also lists interactions of Prilocaine with, for example, Bupivacaine implant, Nitric oxide, Phenazopyridine. The full list is on the Prilocaine page.
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