Drug interactions
Primaquine + Romidepsin
Severity: Moderate
Primaquine and Romidepsin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are associated with QT prolongation, so concurrent use may raise the likelihood of arrhythmias such as torsades de pointes. Patients with cardiac disease or electrolyte disturbances are most vulnerable.
What this interaction means in plain words
Primaquine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic QT prolongation.
What to do
Monitor ECG at baseline and during therapy, and keep potassium and magnesium within normal range. Reassess the combination if QTc lengthens significantly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Primaquine
- Pimozide + Primaquine Contraindicated
- Amiodarone + Primaquine Major
- Amisulpride + Primaquine Major
- Anagrelide + Primaquine Major
- Arsenic trioxide + Primaquine Major
- Asenapine + Primaquine Major
Frequently asked questions
Can I take Primaquine with Romidepsin?
MediHelp rates the interaction as moderate. Primaquine and Romidepsin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs are associated with QT prolongation, so concurrent use may raise the likelihood of arrhythmias such as torsades de pointes. Patients with cardiac disease or electrolyte disturbances are most vulnerable.
How serious is the interaction between Primaquine and Romidepsin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ECG at baseline and during therapy, and keep potassium and magnesium within normal range. Reassess the combination if QTc lengthens significantly.
What other medicines interact with Primaquine?
MediHelp also lists interactions of Primaquine with, for example, Pimozide, Amiodarone, Amisulpride. The full list is on the Primaquine page.
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