Drug interactions
Primidone + Rasagiline
Severity: Minor
Primidone and Rasagiline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized partly to phenobarbital, an enzyme inducer that may increase rasagiline clearance. Rasagiline levels may fall and its effect may diminish.
What this interaction means in plain words
Primidone and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Primidone belongs to Central Nervous System; Rasagiline belongs to Central Nervous System.
Why it happens
Primidone and its phenobarbital metabolite may induce CYP1A2 metabolism of rasagiline.
What to do
Monitor motor symptom control after primidone is started or stopped. Adjust the rasagiline dose if efficacy changes.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rasagiline
- Atomoxetine + Rasagiline Contraindicated
- Brimonidine + Rasagiline Contraindicated
- Bupropion-naltrexone + Rasagiline Contraindicated
- Bupropion + Rasagiline Contraindicated
- Clomipramine + Rasagiline Contraindicated
- Desvenlafaxine + Rasagiline Contraindicated
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Rasagiline?
MediHelp rates the interaction as minor. Primidone and Rasagiline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone is metabolized partly to phenobarbital, an enzyme inducer that may increase rasagiline clearance. Rasagiline levels may fall and its effect may diminish.
How serious is the interaction between Primidone and Rasagiline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor motor symptom control after primidone is started or stopped. Adjust the rasagiline dose if efficacy changes.
What other medicines interact with Rasagiline?
MediHelp also lists interactions of Rasagiline with, for example, Atomoxetine, Brimonidine, Bupropion-naltrexone. The full list is on the Rasagiline page.
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