Drug interactions
Primidone + Rocuronium
Severity: Minor
Primidone and Rocuronium: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital and is an enzyme inducer, so long-term use may reduce response to rocuronium. Shorter block and higher dose requirements are possible.
What this interaction means in plain words
Primidone and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Primidone belongs to Central Nervous System; Rocuronium belongs to Musculoskeletal.
Why it happens
Enzyme induction increasing hepatic clearance of rocuronium, possibly with altered receptor sensitivity.
What to do
Monitor neuromuscular blockade with train-of-four and adjust rocuronium dosing to effect.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rocuronium
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Rocuronium?
MediHelp rates the interaction as minor. Primidone and Rocuronium have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Primidone is metabolized to phenobarbital and is an enzyme inducer, so long-term use may reduce response to rocuronium. Shorter block and higher dose requirements are possible.
How serious is the interaction between Primidone and Rocuronium?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor neuromuscular blockade with train-of-four and adjust rocuronium dosing to effect.
What other medicines interact with Rocuronium?
MediHelp also lists interactions of Rocuronium with, for example, Amikacin, Bacitracin-neomycin-polymyxin, Capreomycin. The full list is on the Rocuronium page.
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