Drug interactions
Primidone + Sorafenib
Severity: Moderate
Primidone and Sorafenib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital, which induces CYP3A4 and other enzymes and may lower sorafenib concentrations. This could reduce the antitumor effect of sorafenib.
What this interaction means in plain words
Primidone and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primidone belongs to Central Nervous System; Sorafenib belongs to Oncology.
Why it happens
Enzyme induction by primidone and its metabolite phenobarbital increases sorafenib metabolism.
What to do
Use a non-inducing anticonvulsant where possible. If the combination is needed, monitor treatment response and sorafenib tolerability.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sorafenib
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Sorafenib?
MediHelp rates the interaction as moderate. Primidone and Sorafenib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital, which induces CYP3A4 and other enzymes and may lower sorafenib concentrations. This could reduce the antitumor effect of sorafenib.
How serious is the interaction between Primidone and Sorafenib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing anticonvulsant where possible. If the combination is needed, monitor treatment response and sorafenib tolerability.
What other medicines interact with Sorafenib?
MediHelp also lists interactions of Sorafenib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sorafenib page.
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