Drug interactions
Primidone + Sunitinib
Severity: Moderate
Primidone and Sunitinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital and induces CYP3A4, which can lower sunitinib exposure and reduce its efficacy.
What this interaction means in plain words
Primidone and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primidone belongs to Central Nervous System; Sunitinib belongs to Oncology.
Why it happens
Primidone and its metabolite phenobarbital induce CYP3A4, increasing sunitinib clearance.
What to do
Use a non-inducing anticonvulsant if possible. If not, consider a sunitinib dose increase per labeling and monitor tolerability and response.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sunitinib
- Adagrasib + Sunitinib Major
- Amiodarone + Sunitinib Major
- Amisulpride + Sunitinib Major
- Anagrelide + Sunitinib Major
- Apalutamide + Sunitinib Major
- Arsenic trioxide + Sunitinib Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Sunitinib?
MediHelp rates the interaction as moderate. Primidone and Sunitinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital and induces CYP3A4, which can lower sunitinib exposure and reduce its efficacy.
How serious is the interaction between Primidone and Sunitinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use a non-inducing anticonvulsant if possible. If not, consider a sunitinib dose increase per labeling and monitor tolerability and response.
What other medicines interact with Sunitinib?
MediHelp also lists interactions of Sunitinib with, for example, Adagrasib, Amiodarone, Amisulpride. The full list is on the Sunitinib page.
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