Drug interactions
Primidone + Vincristine
Severity: Moderate
Primidone and Vincristine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Primidone is metabolized to phenobarbital and induces CYP3A4. Enzyme-inducing anticonvulsants have been shown to increase vincristine clearance, which may reduce its effect.
What this interaction means in plain words
Primidone and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Primidone belongs to Central Nervous System; Vincristine belongs to Oncology.
Why it happens
CYP3A4 induction by primidone and its metabolite phenobarbital increases vincristine clearance.
What to do
Prefer a non-enzyme-inducing anticonvulsant such as levetiracetam during vincristine therapy. If primidone is continued, monitor response to vincristine.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Vincristine
- Adenovirus types 4 and 7 live + Vincristine Contraindicated
- Apalutamide + Vincristine Major
- Atazanavir + Vincristine Major
- Ceritinib + Vincristine Major
- Chloramphenicol + Vincristine Major
- Clarithromycin + Vincristine Major
Other interactions of Primidone
- Lorlatinib + Primidone Contraindicated
- Lurasidone + Primidone Contraindicated
- Primidone + Ranolazine Contraindicated
- Primidone + Sofosbuvir-velpatasvir-voxilaprevir Contraindicated
- Primidone + Voriconazole Contraindicated
- Abiraterone + Primidone Major
Frequently asked questions
Can I take Primidone with Vincristine?
MediHelp rates the interaction as moderate. Primidone and Vincristine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Primidone is metabolized to phenobarbital and induces CYP3A4. Enzyme-inducing anticonvulsants have been shown to increase vincristine clearance, which may reduce its effect.
How serious is the interaction between Primidone and Vincristine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Prefer a non-enzyme-inducing anticonvulsant such as levetiracetam during vincristine therapy. If primidone is continued, monitor response to vincristine.
What other medicines interact with Vincristine?
MediHelp also lists interactions of Vincristine with, for example, Adenovirus types 4 and 7 live, Apalutamide, Atazanavir. The full list is on the Vincristine page.
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