Drug interactions
Probenecid + Rifampin
Severity: Moderate
Probenecid and Rifampin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid can raise rifampin plasma concentrations, which may increase the risk of rifampin adverse effects such as hepatotoxicity. The interaction is not fully characterized clinically.
What this interaction means in plain words
Probenecid and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probenecid is thought to inhibit hepatic uptake of rifampin via OATP and related transporters, reducing its clearance.
What to do
Monitor liver function tests and for rifampin adverse effects when the two are combined. Consider avoiding the combination if hepatic abnormalities develop.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Rifampin?
MediHelp rates the interaction as moderate. Probenecid and Rifampin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid can raise rifampin plasma concentrations, which may increase the risk of rifampin adverse effects such as hepatotoxicity. The interaction is not fully characterized clinically.
How serious is the interaction between Probenecid and Rifampin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and for rifampin adverse effects when the two are combined. Consider avoiding the combination if hepatic abnormalities develop.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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