Drug interactions
Probenecid + Rose hips
Severity: Minor
Probenecid and Rose hips: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rose hips contain vitamin C, an organic acid, and any effect on probenecid is theoretical. Large vitamin C intakes could modestly alter urinary acidification and uric acid handling, but clinically meaningful changes are not established.
What this interaction means in plain words
Probenecid and Rose hips have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for renal organic anion transport; the mechanism is not well established.
What to do
No action is generally required with dietary amounts. If high-dose rose hip or vitamin C supplements are taken, monitor serum uric acid response to probenecid.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Rose hips?
MediHelp rates the interaction as minor. Probenecid and Rose hips have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Rose hips contain vitamin C, an organic acid, and any effect on probenecid is theoretical. Large vitamin C intakes could modestly alter urinary acidification and uric acid handling, but clinically meaningful changes are not established.
How serious is the interaction between Probenecid and Rose hips?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No action is generally required with dietary amounts. If high-dose rose hip or vitamin C supplements are taken, monitor serum uric acid response to probenecid.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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