Drug interactions
Probenecid + Salicylates
Severity: Moderate
Probenecid and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates antagonize the uricosuric effect of probenecid, potentially reducing its efficacy in gout. Salicylates also compete for renal tubular secretion with probenecid. The effect depends on the dose of salicylate.
What this interaction means in plain words
Probenecid and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylates compete with probenecid for renal organic anion transport and inhibit its uricosuric action at the tubule.
What to do
Avoid regular salicylate use in patients taking probenecid for gout; use another analgesic such as paracetamol. If unavoidable, monitor serum uric acid and gout control.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Salicylates?
MediHelp rates the interaction as moderate. Probenecid and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates antagonize the uricosuric effect of probenecid, potentially reducing its efficacy in gout. Salicylates also compete for renal tubular secretion with probenecid. The effect depends on the dose of salicylate.
How serious is the interaction between Probenecid and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular salicylate use in patients taking probenecid for gout; use another analgesic such as paracetamol. If unavoidable, monitor serum uric acid and gout control.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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