Drug interactions
Probenecid + Salsalate
Severity: Moderate
Probenecid and Salsalate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salsalate is hydrolyzed to salicylic acid, which can blunt the uricosuric effect of probenecid. This may reduce control of hyperuricemia and gout.
What this interaction means in plain words
Probenecid and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Salicylate released from salsalate competes with probenecid for renal tubular organic anion transport, antagonizing uricosuria.
What to do
Avoid salsalate in patients using probenecid as a uricosuric; choose an alternative analgesic. If co-used, monitor serum uric acid and gout flares.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Salsalate?
MediHelp rates the interaction as moderate. Probenecid and Salsalate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salsalate is hydrolyzed to salicylic acid, which can blunt the uricosuric effect of probenecid. This may reduce control of hyperuricemia and gout.
How serious is the interaction between Probenecid and Salsalate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid salsalate in patients using probenecid as a uricosuric; choose an alternative analgesic. If co-used, monitor serum uric acid and gout flares.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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