Drug interactions
Probenecid + Sodium phenylacetate
Severity: Moderate
Probenecid and Sodium phenylacetate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid inhibits renal excretion of phenylacetate conjugates, including phenylacetylglutamine, and may raise their levels. This could increase phenylacetate-related toxicity such as neurotoxicity in patients treated for hyperammonemia.
What this interaction means in plain words
Probenecid and Sodium phenylacetate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probenecid inhibits renal tubular secretion of phenylacetate and its conjugates through organic anion transporters.
What to do
Monitor plasma ammonia, phenylacetate levels if available, and for signs of neurotoxicity such as somnolence or confusion. Reduce the phenylacetate dose if toxicity occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Sodium phenylacetate?
MediHelp rates the interaction as moderate. Probenecid and Sodium phenylacetate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid inhibits renal excretion of phenylacetate conjugates, including phenylacetylglutamine, and may raise their levels. This could increase phenylacetate-related toxicity such as neurotoxicity in patients treated for hyperammonemia.
How serious is the interaction between Probenecid and Sodium phenylacetate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor plasma ammonia, phenylacetate levels if available, and for signs of neurotoxicity such as somnolence or confusion. Reduce the phenylacetate dose if toxicity occurs.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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