Drug interactions
Probenecid + Sulfadiazine
Severity: Moderate
Probenecid and Sulfadiazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces renal tubular secretion of sulfonamides and raises sulfadiazine concentrations. Higher levels may increase adverse effects such as crystalluria, hypersensitivity and hematologic toxicity.
What this interaction means in plain words
Probenecid and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probenecid inhibits renal tubular organic anion secretion of sulfadiazine and its metabolites.
What to do
Maintain good hydration and monitor renal function and blood counts. Consider reducing the sulfadiazine dose or avoiding the combination if toxicity emerges.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Sulfadiazine?
MediHelp rates the interaction as moderate. Probenecid and Sulfadiazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces renal tubular secretion of sulfonamides and raises sulfadiazine concentrations. Higher levels may increase adverse effects such as crystalluria, hypersensitivity and hematologic toxicity.
How serious is the interaction between Probenecid and Sulfadiazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Maintain good hydration and monitor renal function and blood counts. Consider reducing the sulfadiazine dose or avoiding the combination if toxicity emerges.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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