Drug interactions
Probenecid + Sulfisoxazole
Severity: Moderate
Probenecid and Sulfisoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces the renal elimination of sulfisoxazole, leading to higher and longer-lasting blood levels. This can increase the chance of sulfonamide-related toxicity.
What this interaction means in plain words
Probenecid and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probenecid inhibits tubular secretion of sulfonamides through organic anion transporters.
What to do
Monitor for rash, cytopenias and crystalluria, and ensure good fluid intake. Reduce the sulfisoxazole dose if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Sulfisoxazole?
MediHelp rates the interaction as moderate. Probenecid and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces the renal elimination of sulfisoxazole, leading to higher and longer-lasting blood levels. This can increase the chance of sulfonamide-related toxicity.
How serious is the interaction between Probenecid and Sulfisoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for rash, cytopenias and crystalluria, and ensure good fluid intake. Reduce the sulfisoxazole dose if adverse effects occur.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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