Drug interactions
Probenecid + Temocillin
Severity: Moderate
Probenecid and Temocillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces renal tubular secretion of temocillin and raises its plasma levels. This can prolong exposure and may increase adverse effects.
What this interaction means in plain words
Probenecid and Temocillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probenecid inhibits renal tubular secretion of temocillin via organic anion transporters.
What to do
Avoid routine coadministration unless increased levels are intended. Monitor renal function and for adverse effects.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Temocillin?
MediHelp rates the interaction as moderate. Probenecid and Temocillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces renal tubular secretion of temocillin and raises its plasma levels. This can prolong exposure and may increase adverse effects.
How serious is the interaction between Probenecid and Temocillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid routine coadministration unless increased levels are intended. Monitor renal function and for adverse effects.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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