Drug interactions
Probenecid + Tenofovir disoproxil
Severity: Moderate
Probenecid and Tenofovir disoproxil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid blocks organic anion transporters that mediate tubular secretion of tenofovir, which may increase tenofovir plasma levels. Higher exposure could increase the risk of renal tubular toxicity.
What this interaction means in plain words
Probenecid and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OAT1/OAT3-mediated renal tubular secretion of tenofovir.
What to do
Monitor serum creatinine, phosphate and urinary protein if the combination is necessary. Consider an alternative to probenecid in patients with reduced renal function.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Tenofovir disoproxil?
MediHelp rates the interaction as moderate. Probenecid and Tenofovir disoproxil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid blocks organic anion transporters that mediate tubular secretion of tenofovir, which may increase tenofovir plasma levels. Higher exposure could increase the risk of renal tubular toxicity.
How serious is the interaction between Probenecid and Tenofovir disoproxil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine, phosphate and urinary protein if the combination is necessary. Consider an alternative to probenecid in patients with reduced renal function.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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