Drug interactions
Probenecid + Ticarcillin
Severity: Moderate
Probenecid and Ticarcillin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid reduces renal tubular secretion of ticarcillin, increasing and prolonging its blood levels. This can be used deliberately, but it raises the risk of dose-related adverse effects.
What this interaction means in plain words
Probenecid and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probenecid blocks organic anion transporter-mediated renal secretion of ticarcillin.
What to do
If coadministration is intended, consider lowering the ticarcillin dose and monitor for adverse effects. Otherwise avoid the combination.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Ticarcillin?
MediHelp rates the interaction as moderate. Probenecid and Ticarcillin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid reduces renal tubular secretion of ticarcillin, increasing and prolonging its blood levels. This can be used deliberately, but it raises the risk of dose-related adverse effects.
How serious is the interaction between Probenecid and Ticarcillin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: If coadministration is intended, consider lowering the ticarcillin dose and monitor for adverse effects. Otherwise avoid the combination.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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