Drug interactions
Probenecid + Willow bark
Severity: Minor
Probenecid and Willow bark: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Willow bark contains salicin, which is converted to salicylic acid and may blunt probenecid's uricosuric effect. Competition for renal secretion may also occur, though the effect depends on the salicylate content.
What this interaction means in plain words
Probenecid and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Salicylate derived from willow bark may compete with probenecid for renal organic anion transport and antagonize uricosuria.
What to do
Avoid regular willow bark products in patients relying on probenecid for gout; monitor serum uric acid if used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Probenecid with Willow bark?
MediHelp rates the interaction as minor. Probenecid and Willow bark have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Willow bark contains salicin, which is converted to salicylic acid and may blunt probenecid's uricosuric effect. Competition for renal secretion may also occur, though the effect depends on the salicylate content.
How serious is the interaction between Probenecid and Willow bark?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid regular willow bark products in patients relying on probenecid for gout; monitor serum uric acid if used.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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