Drug interactions
Procainamide + Umeclidinium-vilanterol
Severity: Moderate
Procainamide and Umeclidinium-vilanterol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procainamide prolongs the QT interval and vilanterol, as a beta-2 agonist, can add to cardiac repolarization effects and cause hypokalemia and tachycardia. Together they may increase the risk of ventricular arrhythmias including torsades de pointes.
What this interaction means in plain words
Procainamide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive QT prolongation and pro-arrhythmic effects from a class IA antiarrhythmic and a beta-2 agonist, with possible beta-agonist-induced hypokalemia.
What to do
Obtain a baseline ECG and monitor QTc and serum potassium and magnesium, correcting deficits. Consider an alternative if the patient has other QT risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Umeclidinium-vilanterol
Frequently asked questions
Can I take Procainamide with Umeclidinium-vilanterol?
MediHelp rates the interaction as moderate. Procainamide and Umeclidinium-vilanterol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procainamide prolongs the QT interval and vilanterol, as a beta-2 agonist, can add to cardiac repolarization effects and cause hypokalemia and tachycardia. Together they may increase the risk of ventricular arrhythmias including torsades de pointes.
How serious is the interaction between Procainamide and Umeclidinium-vilanterol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Obtain a baseline ECG and monitor QTc and serum potassium and magnesium, correcting deficits. Consider an alternative if the patient has other QT risk factors.
What other medicines interact with Umeclidinium-vilanterol?
MediHelp also lists interactions of Umeclidinium-vilanterol with, for example, Aclidinium, Amiodarone, Amitriptyline. The full list is on the Umeclidinium-vilanterol page.
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