Drug interactions
Procarbazine + Rabies vaccine chick embryo cell derived
Severity: Moderate
Procarbazine and Rabies vaccine chick embryo cell derived: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine may blunt the antibody response to chick-embryo-cell rabies vaccine. Reduced protection is important given the fatal nature of rabies.
What this interaction means in plain words
Procarbazine and Rabies vaccine chick embryo cell derived can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression blunts the humoral response to vaccine antigens.
What to do
Check rabies neutralizing antibody titers after vaccination in patients on procarbazine and give post-exposure prophylaxis with immune globulin as indicated.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Rabies vaccine chick embryo cell derived?
MediHelp rates the interaction as moderate. Procarbazine and Rabies vaccine chick embryo cell derived can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine may blunt the antibody response to chick-embryo-cell rabies vaccine. Reduced protection is important given the fatal nature of rabies.
How serious is the interaction between Procarbazine and Rabies vaccine chick embryo cell derived?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check rabies neutralizing antibody titers after vaccination in patients on procarbazine and give post-exposure prophylaxis with immune globulin as indicated.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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