Drug interactions
Procarbazine + Rabies vaccine
Severity: Moderate
Procarbazine and Rabies vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine-related immunosuppression may reduce the antibody response to rabies vaccine. Inadequate titers could be dangerous after exposure to rabies.
What this interaction means in plain words
Procarbazine and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression blunts the humoral response to vaccine antigens.
What to do
For post-exposure prophylaxis, give the full vaccine course with immune globulin as indicated and check the rabies neutralizing antibody titer afterwards; for pre-exposure vaccination, complete it before procarbazine when possible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Rabies vaccine?
MediHelp rates the interaction as moderate. Procarbazine and Rabies vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine-related immunosuppression may reduce the antibody response to rabies vaccine. Inadequate titers could be dangerous after exposure to rabies.
How serious is the interaction between Procarbazine and Rabies vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: For post-exposure prophylaxis, give the full vaccine course with immune globulin as indicated and check the rabies neutralizing antibody titer afterwards; for pre-exposure vaccination, complete it before procarbazine when possible.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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