Drug interactions
Procarbazine + Rotavirus oral vaccine live
Severity: Contraindicated
Procarbazine and Rotavirus oral vaccine live: contraindicated interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine suppresses bone marrow and immune function, so a live-attenuated vaccine may replicate unchecked and cause disease from the vaccine strain. The vaccine response may also be inadequate.
What this interaction means in plain words
Procarbazine and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression from procarbazine impairs control of live vaccine organisms and blunts the immune response to the vaccine.
What to do
Do not give live vaccines during procarbazine therapy; defer them until at least about 3 months after chemotherapy ends and immune recovery is confirmed. Use inactivated vaccines where appropriate.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Rotavirus oral vaccine live?
MediHelp rates the interaction as contraindicated. Procarbazine and Rotavirus oral vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine suppresses bone marrow and immune function, so a live-attenuated vaccine may replicate unchecked and cause disease from the vaccine strain. The vaccine response may also be inadequate.
How serious is the interaction between Procarbazine and Rotavirus oral vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live vaccines during procarbazine therapy; defer them until at least about 3 months after chemotherapy ends and immune recovery is confirmed. Use inactivated vaccines where appropriate.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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