Drug interactions
Procarbazine + Rubella vaccine
Severity: Contraindicated
Procarbazine and Rubella vaccine: contraindicated interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine is immunosuppressive, so the live rubella vaccine virus may replicate excessively and cause disseminated infection. Protective antibody response may also be poor.
What this interaction means in plain words
Procarbazine and Rubella vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Chemotherapy-induced immunosuppression impairs clearance of live attenuated virus and reduces vaccine immunogenicity.
What to do
Avoid live rubella vaccine during procarbazine treatment and delay it until at least about 3 months after therapy with immune recovery. Revaccinate later if needed.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Rubella vaccine?
MediHelp rates the interaction as contraindicated. Procarbazine and Rubella vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Procarbazine is immunosuppressive, so the live rubella vaccine virus may replicate excessively and cause disseminated infection. Protective antibody response may also be poor.
How serious is the interaction between Procarbazine and Rubella vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid live rubella vaccine during procarbazine treatment and delay it until at least about 3 months after therapy with immune recovery. Revaccinate later if needed.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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