Drug interactions
Procarbazine + Same
Severity: Major
Procarbazine and Same: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has weak monoamine oxidase inhibiting activity, and S-adenosylmethionine (SAMe) may raise central serotonin and other monoamine activity. Together they may contribute to serotonin syndrome, with agitation, hyperthermia, tremor, clonus and autonomic instability.
What this interaction means in plain words
Procarbazine and Same can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive serotonergic effect from MAO inhibition by procarbazine and increased monoamine synthesis or availability with SAMe.
What to do
Avoid SAMe in patients receiving procarbazine and stop it before starting therapy. If it is taken, monitor for signs of serotonin toxicity and discontinue SAMe if they appear.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Same?
MediHelp rates the interaction as major. Procarbazine and Same can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Procarbazine has weak monoamine oxidase inhibiting activity, and S-adenosylmethionine (SAMe) may raise central serotonin and other monoamine activity. Together they may contribute to serotonin syndrome, with agitation, hyperthermia, tremor, clonus and autonomic instability.
How serious is the interaction between Procarbazine and Same?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid SAMe in patients receiving procarbazine and stop it before starting therapy. If it is taken, monitor for signs of serotonin toxicity and discontinue SAMe if they appear.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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