Drug interactions
Procarbazine + Serdexmethylphenidate / dexmethylphenidate
Severity: Contraindicated
Procarbazine and Serdexmethylphenidate / dexmethylphenidate: contraindicated interaction.
Last updated Sources: Health Canada product monograph
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Methylphenidate-type stimulants given with or shortly after an MAO inhibitor such as procarbazine can provoke severe hypertension and hypertensive crisis. This is a labeled contraindication for the stimulant.
What this interaction means in plain words
Procarbazine and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO inhibition allows catecholamine accumulation while the stimulant increases norepinephrine and dopamine release.
What to do
Avoid concurrent use and for at least 14 days after stopping an MAOI before starting the stimulant. Use a non-interacting alternative.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates the interaction as contraindicated. Procarbazine and Serdexmethylphenidate / dexmethylphenidate are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Methylphenidate-type stimulants given with or shortly after an MAO inhibitor such as procarbazine can provoke severe hypertension and hypertensive crisis. This is a labeled contraindication for the stimulant.
How serious is the interaction between Procarbazine and Serdexmethylphenidate / dexmethylphenidate?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and for at least 14 days after stopping an MAOI before starting the stimulant. Use a non-interacting alternative.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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