Drug interactions
Procarbazine + Smallpox vaccine live
Severity: Contraindicated
Procarbazine and Smallpox vaccine live: contraindicated interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
In an immunosuppressed patient, the live vaccinia virus can spread progressively and cause serious vaccine-related infection. The vaccine response is also likely to be reduced.
What this interaction means in plain words
Procarbazine and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Procarbazine-induced immunosuppression permits uncontrolled replication of live vaccinia virus and blunts immunity.
What to do
Do not give live smallpox vaccine during procarbazine therapy; defer until immune recovery, usually at least about 3 months after stopping. Seek specialist advice if exposure risk is high.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Procarbazine and Smallpox vaccine live, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Smallpox vaccine live?
MediHelp rates the interaction as contraindicated. Procarbazine and Smallpox vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. In an immunosuppressed patient, the live vaccinia virus can spread progressively and cause serious vaccine-related infection. The vaccine response is also likely to be reduced.
How serious is the interaction between Procarbazine and Smallpox vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give live smallpox vaccine during procarbazine therapy; defer until immune recovery, usually at least about 3 months after stopping. Seek specialist advice if exposure risk is high.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
