Drug interactions
Procarbazine + Sumatriptan intranasal
Severity: Contraindicated
Procarbazine and Sumatriptan intranasal: contraindicated interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO-A inhibition reduces sumatriptan metabolism, increasing exposure and raising the risk of serotonin toxicity and vasoconstrictive effects. Sumatriptan labeling contraindicates use with or within 2 weeks of an MAO-A inhibitor.
What this interaction means in plain words
Procarbazine and Sumatriptan intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
MAO-A inhibition decreases sumatriptan clearance and adds serotonergic effects.
What to do
Avoid use; wait at least 2 weeks after stopping the MAOI. Consider a triptan not metabolised by MAO-A, such as naratriptan, eletriptan or frovatriptan, with monitoring for serotonin syndrome.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Sumatriptan intranasal?
MediHelp rates the interaction as contraindicated. Procarbazine and Sumatriptan intranasal are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. MAO-A inhibition reduces sumatriptan metabolism, increasing exposure and raising the risk of serotonin toxicity and vasoconstrictive effects. Sumatriptan labeling contraindicates use with or within 2 weeks of an MAO-A inhibitor.
How serious is the interaction between Procarbazine and Sumatriptan intranasal?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid use; wait at least 2 weeks after stopping the MAOI. Consider a triptan not metabolised by MAO-A, such as naratriptan, eletriptan or frovatriptan, with monitoring for serotonin syndrome.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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