Drug interactions
Procarbazine + Tetanus toxoid adsorbed or fluid
Severity: Moderate
Procarbazine and Tetanus toxoid adsorbed or fluid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine may reduce the antibody response to tetanus toxoid. Protective antitoxin levels may not be reached.
What this interaction means in plain words
Procarbazine and Tetanus toxoid adsorbed or fluid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Chemotherapy-induced immunosuppression blunts the humoral response to vaccine antigens.
What to do
Vaccinate at least 2 weeks before procarbazine if possible; for wound management during therapy, give tetanus immune globulin as indicated and consider revaccination about 3 months after treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Tetanus toxoid adsorbed or fluid?
MediHelp rates the interaction as moderate. Procarbazine and Tetanus toxoid adsorbed or fluid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine may reduce the antibody response to tetanus toxoid. Protective antitoxin levels may not be reached.
How serious is the interaction between Procarbazine and Tetanus toxoid adsorbed or fluid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before procarbazine if possible; for wound management during therapy, give tetanus immune globulin as indicated and consider revaccination about 3 months after treatment.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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