Drug interactions
Procarbazine + Thiothixene
Severity: Moderate
Procarbazine and Thiothixene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine has MAO inhibiting activity and may add to the serotonergic and dopamine-modulating effects of antipsychotics. This could raise the risk of serotonin toxicity or neuroleptic malignant syndrome, along with additive sedation. Evidence is mainly theoretical.
What this interaction means in plain words
Procarbazine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Weak MAO inhibition by procarbazine combined with antipsychotic dopamine blockade may produce additive serotonergic and dopaminergic effects.
What to do
Monitor for hyperthermia, rigidity, clonus, agitation and autonomic instability. Stop both drugs and provide supportive care if serotonin syndrome or neuroleptic malignant syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Thiothixene?
MediHelp rates the interaction as moderate. Procarbazine and Thiothixene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine has MAO inhibiting activity and may add to the serotonergic and dopamine-modulating effects of antipsychotics. This could raise the risk of serotonin toxicity or neuroleptic malignant syndrome, along with additive sedation. Evidence is mainly theoretical.
How serious is the interaction between Procarbazine and Thiothixene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for hyperthermia, rigidity, clonus, agitation and autonomic instability. Stop both drugs and provide supportive care if serotonin syndrome or neuroleptic malignant syndrome is suspected.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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