Drug interactions
Procarbazine + Trifluoperazine
Severity: Moderate
Procarbazine and Trifluoperazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Procarbazine and phenothiazines both cause CNS depression, so excessive sedation is possible. Procarbazine's MAO inhibiting activity may also add to serotonergic and dopamine-modulating effects, raising the theoretical risk of serotonin toxicity or neuroleptic malignant syndrome.
What this interaction means in plain words
Procarbazine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive CNS depression plus potential serotonergic and dopaminergic effects from weak MAO inhibition combined with dopamine blockade.
What to do
Monitor sedation level and for hyperthermia, rigidity, clonus and autonomic instability. Lower the trifluoperazine dose if excessive sedation occurs, and stop both drugs if serotonin syndrome or neuroleptic malignant syndrome is suspected.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Trifluoperazine?
MediHelp rates the interaction as moderate. Procarbazine and Trifluoperazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Procarbazine and phenothiazines both cause CNS depression, so excessive sedation is possible. Procarbazine's MAO inhibiting activity may also add to serotonergic and dopamine-modulating effects, raising the theoretical risk of serotonin toxicity or neuroleptic malignant syndrome.
How serious is the interaction between Procarbazine and Trifluoperazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and for hyperthermia, rigidity, clonus and autonomic instability. Lower the trifluoperazine dose if excessive sedation occurs, and stop both drugs if serotonin syndrome or neuroleptic malignant syndrome is suspected.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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