Drug interactions
Procarbazine + Typhoid polysaccharide vaccine
Severity: Moderate
Procarbazine and Typhoid polysaccharide vaccine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Typhoid Vi polysaccharide vaccine is inactivated, so there is no infection risk, but procarbazine-related immunosuppression may reduce the antibody response and leave the patient unprotected. The legacy contraindication is overly strict for this vaccine.
What this interaction means in plain words
Procarbazine and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Immunosuppression from procarbazine impairs the immune response to the vaccine antigen.
What to do
Vaccinate at least 2 weeks before chemotherapy if possible, otherwise give it and consider revaccination after immune recovery. Do not withhold if travel exposure is imminent.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Typhoid polysaccharide vaccine?
MediHelp rates the interaction as moderate. Procarbazine and Typhoid polysaccharide vaccine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Typhoid Vi polysaccharide vaccine is inactivated, so there is no infection risk, but procarbazine-related immunosuppression may reduce the antibody response and leave the patient unprotected. The legacy contraindication is overly strict for this vaccine.
How serious is the interaction between Procarbazine and Typhoid polysaccharide vaccine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Vaccinate at least 2 weeks before chemotherapy if possible, otherwise give it and consider revaccination after immune recovery. Do not withhold if travel exposure is imminent.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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