Drug interactions
Procarbazine + Typhoid vaccine live
Severity: Contraindicated
Procarbazine and Typhoid vaccine live: contraindicated interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
The live oral typhoid vaccine (Ty21a) can cause invasive infection in immunosuppressed patients, and the vaccine response may be poor. Procarbazine causes substantial immunosuppression.
What this interaction means in plain words
Procarbazine and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Chemotherapy-induced immunosuppression allows the live attenuated bacteria to persist and impairs immunity.
What to do
Avoid the live vaccine during therapy and for at least about 3 months afterwards. Use the inactivated injectable typhoid vaccine instead.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Procarbazine and Typhoid vaccine live, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
References
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Typhoid vaccine live?
MediHelp rates the interaction as contraindicated. Procarbazine and Typhoid vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. The live oral typhoid vaccine (Ty21a) can cause invasive infection in immunosuppressed patients, and the vaccine response may be poor. Procarbazine causes substantial immunosuppression.
How serious is the interaction between Procarbazine and Typhoid vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the live vaccine during therapy and for at least about 3 months afterwards. Use the inactivated injectable typhoid vaccine instead.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
