Drug interactions
Procarbazine + Varicella virus vaccine live
Severity: Contraindicated
Procarbazine and Varicella virus vaccine live: contraindicated interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
In patients on procarbazine, live varicella vaccine virus can disseminate and cause severe or fatal varicella-like illness. Immune response may also be inadequate.
What this interaction means in plain words
Procarbazine and Varicella virus vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Immunosuppression permits uncontrolled replication of live attenuated varicella virus.
What to do
Do not give during procarbazine therapy; defer until at least about 3 months after completion with confirmed immune recovery. Consider varicella immune globulin after exposure.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Varicella virus vaccine live?
MediHelp rates the interaction as contraindicated. Procarbazine and Varicella virus vaccine live are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. In patients on procarbazine, live varicella vaccine virus can disseminate and cause severe or fatal varicella-like illness. Immune response may also be inadequate.
How serious is the interaction between Procarbazine and Varicella virus vaccine live?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Do not give during procarbazine therapy; defer until at least about 3 months after completion with confirmed immune recovery. Consider varicella immune globulin after exposure.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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