Drug interactions
Procarbazine + Yellow fever vaccine
Severity: Contraindicated
Procarbazine and Yellow fever vaccine: contraindicated interaction.
Last updated Sources: Base de donnees publique des medicaments (France)
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live yellow fever vaccine carries risk of vaccine-associated viscerotropic or neurotropic disease in immunosuppressed patients, and protection may be inadequate. Procarbazine is significantly immunosuppressive.
What this interaction means in plain words
Procarbazine and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two.
Why it happens
Chemotherapy-induced immunosuppression allows excessive replication of the live vaccine virus and reduces immunogenicity.
What to do
Avoid vaccination during therapy and delay until about 3 months after it ends. If travel to endemic areas is unavoidable, advise a medical waiver letter and mosquito protection.
What to ask your pharmacist
- Is there an alternative to one of these two medicines for me?
- If both are essential, who is monitoring me and how often?
- Which symptoms mean I should stop and seek help straight away?
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References
Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Yellow fever vaccine?
MediHelp rates the interaction as contraindicated. Procarbazine and Yellow fever vaccine are not normally used together. Taking them at the same time is expected to cause harm or make one of them unsafe, so a different medicine is usually chosen for one of the two. Live yellow fever vaccine carries risk of vaccine-associated viscerotropic or neurotropic disease in immunosuppressed patients, and protection may be inadequate. Procarbazine is significantly immunosuppressive.
How serious is the interaction between Procarbazine and Yellow fever vaccine?
MediHelp rates it contraindicated, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid vaccination during therapy and delay until about 3 months after it ends. If travel to endemic areas is unavoidable, advise a medical waiver letter and mosquito protection.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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