Drug interactions
Procarbazine + Yohimbe
Severity: Major
Procarbazine and Yohimbe: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Yohimbine has alpha-2 antagonist activity that increases noradrenergic outflow, and combining it with an MAO inhibitor such as procarbazine may cause hypertension, tachycardia, anxiety or agitation. Herbal yohimbe products vary widely in content, making the effect less predictable.
What this interaction means in plain words
Procarbazine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Increased norepinephrine release from alpha-2 blockade combined with reduced catecholamine breakdown through MAO inhibition.
What to do
Avoid yohimbe products in patients taking procarbazine. Monitor blood pressure and heart rate if exposure has occurred.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Procarbazine
- Adenovirus types 4 and 7 live + Procarbazine Contraindicated
- Amitriptyline + Procarbazine Contraindicated
- Amoxapine + Procarbazine Contraindicated
- Atomoxetine + Procarbazine Contraindicated
- Bcg vaccine live + Procarbazine Contraindicated
- Brimonidine + Procarbazine Contraindicated
Frequently asked questions
Can I take Procarbazine with Yohimbe?
MediHelp rates the interaction as major. Procarbazine and Yohimbe can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Yohimbine has alpha-2 antagonist activity that increases noradrenergic outflow, and combining it with an MAO inhibitor such as procarbazine may cause hypertension, tachycardia, anxiety or agitation. Herbal yohimbe products vary widely in content, making the effect less predictable.
How serious is the interaction between Procarbazine and Yohimbe?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid yohimbe products in patients taking procarbazine. Monitor blood pressure and heart rate if exposure has occurred.
What other medicines interact with Procarbazine?
MediHelp also lists interactions of Procarbazine with, for example, Adenovirus types 4 and 7 live, Amitriptyline, Amoxapine. The full list is on the Procarbazine page.
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