Drug interactions
Promazine + Sertraline
Severity: Moderate
Promazine and Sertraline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promazine is a phenothiazine partly metabolized by CYP2D6, and sertraline can inhibit this enzyme, possibly raising promazine levels. Both drugs may prolong the QT interval and cause sedation, so the effect may be additive.
What this interaction means in plain words
Promazine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
CYP2D6 inhibition by sertraline plus additive QT prolongation and sedation.
What to do
Monitor for sedation, orthostatic hypotension and extrapyramidal symptoms, and consider an ECG if other QT risks are present. Lower the promazine dose if adverse effects appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Sertraline
- Isocarboxazid + Sertraline Contraindicated
- Methylene blue + Sertraline Contraindicated
- Phenelzine + Sertraline Contraindicated
- Pimozide + Sertraline Contraindicated
- Selegiline transdermal + Sertraline Contraindicated
- Selegiline + Sertraline Contraindicated
Frequently asked questions
Can I take Promazine with Sertraline?
MediHelp rates the interaction as moderate. Promazine and Sertraline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Promazine is a phenothiazine partly metabolized by CYP2D6, and sertraline can inhibit this enzyme, possibly raising promazine levels. Both drugs may prolong the QT interval and cause sedation, so the effect may be additive.
How serious is the interaction between Promazine and Sertraline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, orthostatic hypotension and extrapyramidal symptoms, and consider an ECG if other QT risks are present. Lower the promazine dose if adverse effects appear.
What other medicines interact with Sertraline?
MediHelp also lists interactions of Sertraline with, for example, Isocarboxazid, Methylene blue, Phenelzine. The full list is on the Sertraline page.
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